Platelet factor 4 binds to bacteria, inducing antibodies cross-reacting with the major antigen in heparin-induced thrombocytopenia
نویسندگان
چکیده
1Institut für Immunologie und Transfusionsmedizin, Ernst-Moritz-Arndt Universität, Greifswald, Germany; 2Genetik der Mikroorganismen, Interfakultäres Institut für Genetik und Funktionelle Genomforschung, Ernst-Moritz-Arndt Universität, Greifswald, Germany; 3Klinik und Poliklinik für Allgemeine Chirurgie, Viszeral-, Thoraxund Gefässchirurgie, Ernst-Moritz-Arndt Universität, Greifswald, Germany; and 4Institut für Community Medicine, Ernst-Moritz-Arndt-Universität, Greifswald, Germany
منابع مشابه
PLATELETS AND THROMBOPOIESIS Platelet factor 4 binds to bacteria, inducing antibodies cross-reacting with the major antigen in heparin-induced thrombocytopenia
1Institut für Immunologie und Transfusionsmedizin, Ernst-Moritz-Arndt Universität, Greifswald, Germany; 2Genetik der Mikroorganismen, Interfakultäres Institut für Genetik und Funktionelle Genomforschung, Ernst-Moritz-Arndt Universität, Greifswald, Germany; 3Klinik und Poliklinik für Allgemeine Chirurgie, Viszeral-, Thoraxund Gefässchirurgie, Ernst-Moritz-Arndt Universität, Greifswald, Germany; ...
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The positively charged chemokine platelet factor 4 (PF4) forms immunogenic complexes with heparin and other polyanions. Resulting antibodies can induce the adverse drug effect heparin-induced thrombocytopenia. PF4 also binds to bacteria, thereby exposing the same neoantigen(s) as with heparin. In this study, we identified the negatively charged lipopolysaccharide (LPS) as the PF4 binding struct...
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